PHM SCI 254 — TINY EARTH GENOMICS - RESEARCHING UNCULTURED ANTIBIOTIC-PRODUCING MICROBES

3 credits.

Collaborate on a research project from the conception of research questions through data analysis and the effective communication of results. Explore the biosynthesis of antibiotics and other small molecules by uncultured bacteria through the analysis of culture-independent DNA sequencing (metagenomics) data, learning about bioinformatics and genomics along the way. Make new discoveries of microbial species and biochemical pathways.

PHM SCI 310 — DRUGS AND THEIR ACTIONS

2 credits.

Introduces students to the biological effects of drugs on human health. Emphasis on how drugs, especially those used in diseases of major human health significance, act in the body. Drugs that are abused also will be covered. This course is not intended for medical, nursing, pharmacy, and physician assistant students.

PHM SCI 420 — PHYSICOCHEMICAL PRINCIPLES OF DRUG FORMULATION AND DELIVERY

3 credits.

Applications of physicochemical principles to pharmaceutical systems.

PHM SCI/​B M E  430 — BIOLOGICAL INTERACTIONS WITH MATERIALS

3 credits.

Addresses the range of materials currently being utilized for various biomedical applications, the biological systems governing biomaterial applications, analytical techniques pertinent to biomaterial evaluation, and selected major medical applications in which biomaterials play an important role.

PHM SCI 432 — BIOCHEMICAL PRINCIPLES OF DRUG TREATMENT

3 credits.

Basic biochemistry as the biochemical basis for drug action. Focus on biopolymers (proteins, nucleic acids) as intended and unintended targets of current drug therapy and the major biochemical pathways in which they operate. Review of protein structure, enzymatic activity, metabolic pathways, membrane biochemistry, mechanism of drug action, DNA mutation and repair.

PHM SCI 490 — SELECTED TOPICS IN PHARMACEUTICAL SCIENCES

1-4 credits.

Specialized subject matter of current interest to undergraduate and professional students.

PHM SCI 493 — SELECTED TOPICS IN PHARMACEUTICAL SCIENCES

1-4 credits.

Specialized subject matter of current interest to graduate students.

PHM SCI 510 — PHARMACOLOGY PRINCIPLES AND APPLICATIONS

2 credits.

Underlying science and pharmacological actions of drugs and the biological effects of drugs on human health. Covers drugs used to treat common illnesses and diseases as well as commonly abused drugs.

PHM SCI 521 — PHARMACOLOGY I

3 credits.

Pharmacological actions of important drugs, including drugs that affect the peripheral and central nervous systems.

PHM SCI/​PHMCOL-M  522 — PHARMACOLOGY II

3-4 credits.

Pharmacological actions of important drugs, including hematopoietic, thrombolytic, antihyperlipidemic, immunopharmacologic, anticancer, anti-inflammatory, diuretic, antihypertensive, antianginal, and anti-arrhythmic agents, and agents used to treat congestive heart failure.

PHM SCI 531 — MEDICINAL CHEMISTRY I

3 credits.

Basic concepts in the chemistry of small molecule medicinal products. Structure activity of cholinergic, adrenergic, serotonergic and dopaminergic agents, antidepressant, antianxiety drugs, opioids, and antihistamines. Overview of drug metabolism and the clinical effects of metabolic drug interactions and genetic variability in drug metabolism genes.

PHM SCI 532 — MEDICINAL CHEMISTRY II

2 credits.

Chemistry of medicinal products, including antihyperlipidemics, glucocorticoids, estrogens, progestins, nonsteroidal anti-inflammatories, antitumor agents, and enzyme inhibitors.

PHM SCI 540 — DRUG DELIVERY SYSTEMS FOR PHARMACOTHERAPY

3 credits.

A series of lectures by experts covering: i) introductory drug development and delivery system development processes; ii) various drug delivery routes (oral, topical, rectal, vaginal, urethral, nasal, and pulmonary); iii) various delivery systems (conventional, ophthalmic, CNS, and recent advances); iv) delivery systems related to biofilms, infection, and vaccines.

PHM SCI 541 — PHARMACEUTICAL CALCULATIONS, DISPENSING AND COMPOUNDING

3 credits.

Introductory laboratory course in compounding and dispensing of pharmaceutical dosage forms, including sterile products. Includes practice in interpretation of prescription orders, pharmaceutical calculations, compounding procedures, physical manipulation of drugs and dosage form components, and product packaging and labeling.

PHM SCI 542 — PARENTERAL THERAPY AND NUTRITION

3 credits.

An introduction to parenteral therapy and nutrition focusing on the fundamental properties, calculations involved and the methods to prepare safe and reliable injectable medications for patients.

PHM SCI 558 — LABORATORY TECHNIQUES IN PHARMACOLOGY AND TOXICOLOGY

2 credits.

Basic laboratory techniques employed in pharmacological and toxicological research.

PHM SCI 581 — MOLECULAR AND CELLULAR PRINCIPLES IN PHARMACOLOGY

4 credits.

In-depth introduction to the molecular and cellular principles of pharmacology. Emphasis on the mechanisms of drug and small molecule action in cells, with a focus on downstream signaling pathways, second messenger systems, protein kinase cascades, and the regulation of gene transcription.

PHM SCI 623 — PHARMACOLOGY III

3 credits.

Pharmacological actions and underlying basic and clinical science of antimicrobial and antiviral drugs. Pharmacology of hormones and other drugs affecting the endocrine system.

PHM SCI/​M&ENVTOX/​ONCOLOGY/​PHMCOL-M/​POP HLTH  625 — TOXICOLOGY I

3 credits.

Basic principles of toxicology and biochemical mechanisms of toxicity in mammalian species and man. Correlation between morphological and functional changes caused by toxicants in different organs of the body.

PHM SCI/​M&ENVTOX/​PATH/​PHMCOL-M/​POP HLTH  626 — TOXICOLOGY II

3 credits.

Survey of the basic methods and fundamental biochemical mechanisms of toxicity. Toxicity in mammalian organ systems, techniques for evaluating toxicity, as well as mechanisms of species specificity, and environmental interactions (with toxicant examples) are presented.

PHM SCI 679 — PHARMACOLOGY AND TOXICOLOGY SEMINAR

1 credit.

Senior student presentations of independent research or of published papers on a specific topic approved by the course coordinator. Faculty-led seminars on selected topics regarding responsible conduct of research. The course also provides a venue for career talks by Pharmacology and Toxicology alumni and guests working in a variety of professional settings - research, industry (pharmaceutical; biotech; contract research; consumer products; etc.), a variety of healthcare professions, and law.

PHM SCI 680 — PRINCIPLES OF PHARMACEUTICAL SCIENCES

3 credits.

Learn about essential components of drug development and cutting-edge research in drug discovery, drug action, and drug delivery. Focus on useful and practical information and essential underpinnings in chemistry, biology, physical chemistry, and engineering.

PHM SCI 691 — SENIOR THESIS

2 credits.

Individual study for seniors completing theses as arranged with a faculty member.

PHM SCI 692 — SENIOR THESIS

2 credits.

Individual study for seniors completing theses as arranged with a faculty member.

PHM SCI 699 — ADVANCED INDEPENDENT STUDY

0-3 credits.

Directed study projects as arranged with a faculty member.

PHM SCI 751 — INTRODUCTION TO REGULATORY PRACTICE

3 credits.

Identifies and examines the key regulatory agencies and practices that govern the highly regulated and diverse pharmaceutical industry. Highlights current and emerging FDA and ICH regulations and guidance documents to successfully navigate meeting with the agencies and to submit required documentation for successful product development.

PHM SCI 752 — GXP (GOOD PRACTICE): WORKING IN A REGULATED ENVIRONMENT

3 credits.

The pharmaceutical and biopharmaceutical industries have strict documentation and production requirements. Prepares the learner to work in a regulated environment. Explains roles and responsibilities across multiple disciplines and proper documentation practices. Prepares learner for protocol, report creation and audit responses. Discusses specifications, guidances and root-cause analysis.

PHM SCI 753 — PROJECT MANAGEMENT IN DRUG DEVELOPMENT

3 credits.

Key concepts and body of knowledge of Project Management (PM) applied to the specifics of the drug development process. PM theory and language. The life cycle of a project: Initiating, Planning, Executing, Monitoring and Control, and Closing. Predictive, adaptive and hybrid PM frameworks and tools. Project Charter, statement-of-work, scope of work, work-breakdown structure, project network and timelines. Critical path method and earned value analysis to adjust schedules, allocate resources, and implement corrective actions. Risk management in pharmaceutical projects. An overview of documents management and decision-making strategies.

PHM SCI 754 — LIFECYCLE MANAGEMENT OF PHARMACEUTICAL PRODUCTS

3 credits.

Explores the process of bringing pharmaceutical products to market, particularly as it applies to the scaling up, manufacturing, and maintenance phases that come after FDA approval of a product is obtained. Identifies various factors that impact the life cycle management of pharmaceutical products from development to sustained large-scale distribution, such as: target product profile (TPP), chemistry, manufacturing and controls (CMC), active pharmaceutical ingredient (API) supply chain considerations, raw materials shortages, demand planning/forecasting, and post-approval regulatory considerations.

PHM SCI 755 — LABORATORY AND INSTRUMENTATION METHODS

3 credits.

Teaches the theory and application of many common laboratory techniques and instruments used in drug discovery and development. Includes a laboratory component to teach safety and basic techniques necessary for working in a lab. Instruction begins with basic techniques and builds upon these techniques to instruct in proper sample preparation and handling for analysis using a variety of analytical instrumentation.

PHM SCI 756 — INTRODUCTION TO DATA ANALYSES IN DRUG DEVELOPMENT

3 credits.

Provides a high-level overview of how data analysis techniques augment the drug discovery and development process. Focuses on project-based skills-building through the application of industry-standard software and use of public databases. Explores best practices for data processing and management to ensure experimental reproducibility. Develops troubleshooting skills through critical evaluation of data analysis results and root cause analysis.

PHM SCI 757 — INTRODUCTION TO DRUG DEVELOPMENT

2 credits.

Scientific process of drug development from discovery through clinical trials. Brief history of drug development, along with an overview of drug discovery, preclinical, and clinical activities that take place during development. Application to real-world drug development scenarios and challenges, especially as they apply to development of drugs to treat neurological diseases.

PHM SCI 759 — CURRENT TRENDS IN DRUG DISCOVERY AND DEVELOPMENT

1 credit.

Provides the experience and skill to find, read and critically analyze scientific and regulatory literature in the field of drug discovery and development.

PHM SCI 760 — SUMMATIVE RESEARCH INTERNSHIP

3-4 credits.

Summation of core coursework to a real-world project and/or internship experience. Synthesis of knowledge, skills and abilities to demonstrate aptitude for careers in respective industries.

PHM SCI 761 — INTRODUCTION TO PHARMACOLOGY

1 credit.

Introduction to basic concepts of drug delivery and action, methods used to study drug action. Includes a brief survey of drugs acting on the cardiovascular system, the central nervous system and other drug targets.

PHM SCI 762 — THE DRUG DEVELOPMENT PROCESS FROM DISCOVERY TO INVESTIGATIONAL NEW DRUG APPLICATION (IND)

3 credits.

Overview of the drug development process from discovery to investigational new drug application (IND). Drug discovery (target identification, target validation, and hit-to-lead) preclinical CMC activities, and preclinical pharmacology, pharmacokinetic, and toxicology studies as they apply to both small and large molecule drugs.

PHM SCI 763 — THE DRUG DEVELOPMENT PROCESS FROM FIH TO BLA/NDA

3 credits.

Overview of the drug development process from first-in-human (FIH) to submission of a new drug application (NDA) or biologics license application (BLA). Phases of clinical development and the role of biomarkers, companion diagnostics, statistical analysis, and CMC in clinical trials. Both small molecule and protein therapeutics will be addressed.

PHM SCI/​CHEM  766 — MOLECULAR RECOGNITION

2-3 credits.

Origin, nature, classification, and description of intermolecular forces. The hydrophobic effect. Molecular complexes, binding constants, and their measurements. General principles of self-assembly, molecular recognition, complex formation, host design. Supramolecular systems and their dynamics. Micelles, bilayers, vesicles, biological membranes.

PHM SCI 768 — PHARMACOKINETICS

3 credits.

Quantitative aspects of drug absorption, distribution, metabolism, and excretion. Philosophy and applications of pharmacokinetic modeling and its use in clinical practice.

PHM SCI 773 — MOLECULAR SOLIDS

2-3 credits.

Science and technology of molecular solid materials with applications in medicine, food, energetic materials, and organic electronics.

PHM SCI 775 — POLYMERIC DRUG DELIVERY

3 credits.

Introduces synthetic and biological polymers applied for drug targeting and controlled drug release, focusing on injectable drugs, including biologics.

PHM SCI 786 — NATURAL PRODUCT SYNTHESIS, BIOSYNTHESIS AND DRUG DISCOVERY

3 credits.

Synthesis and biosynthesis of natural products in drug discovery. Topics include: natural products in drug discovery; biosynthetic pathways and synthetic strategies for major natural product classes; and basic bioorganic chemistry and enzyme mechanisms in biosynthesis.

PHM SCI 931 — PHARMACEUTICAL SCIENCES SEMINAR

1 credit.

Weekly series that provides exposure to a diverse array of research topics. Students enroll in one of three sections, corresponding to their research core (Drug Action, Drug Discovery, or Drug Delivery). Students in their 2nd year and beyond present their research progress or review literature. The course includes talks from nationally and internationally recognized scientists from academia and industry.

PHM SCI 932 — PHARMACEUTICAL SCIENCES SEMINAR

1 credit.

Weekly series that provides exposure to a diverse array of research topics. Students enroll in one of three sections, corresponding to their research core (Drug Action, Drug Discovery, or Drug Delivery). Students in their 2nd-year and beyond present their research progress or review literature. The course includes talks from nationally and internationally recognized scientists from academia and industry.

PHM SCI 990 — RESEARCH

1-12 credits.

Independent research and writing for graduate and students under the supervision of a faculty member.

PHM SCI 999 — ADVANCED INDEPENDENT STUDY

1-12 credits.

Directed study projects for graduate students as arranged with a faculty member.