B M E 1 — Cooperative Education Program

1 credit.

Work experience which combines classroom theory with practical knowledge of operations providing a background upon which to base a professional career in industry.

B M E 200 — Biomedical Engineering Design

2 credits.

Collaborate with students in B M E 300 on a client-centered biomedical engineering design project to learn concept generation, product analysis, specifications, evaluation, regulation, and ethics.

B M E 201 — Biomedical Engineering Design and Fundamentals

3 credits.

Fundamentals of biomedical engineering and principles of design including the design process, standards, documentation, inclusion in design and research methods. Hands-on skills including electronics, programming, computer-aided design, machining, safety training, microscopy, cell and tissue engineering principles and fabrication of physical prototypes.

B M E 300 — Biomedical Engineering Design and Leadership

3 credits.

Work on a client-centered biomedical engineering design project to learn leadership styles, concept generation, product analysis, specifications, evaluation, regulation, and ethics. Provide leadership and mentorship to students in B M E 200.

B M E 310 — Bioinstrumentation

3 credits.

Bioinstrumentation covering clinical and research measurements. Laboratory experiments complement the lectures.

B M E 315 — Biomechanics

3 credits.

An introduction to the mechanical behavior of biological tissues and systems. Specific topics include: structure and function of biological tissues, mechanical properties of biological tissues, and analysis of specific tissues (i.e. bone, muscle, and soft connective tissues).

B M E 325 — Applied Statistics for Biomedical Engineers

3 credits.

Learn and apply the fundamentals of descriptive and inferential statistics to analyze data and present the results in appropriate graphical formats. Emphasis will be on applications commonly encountered in biomedical engineering including t-tests, linear regression, analysis of variance, diagnostic tests, ROC curves, and methods for graphing and presenting data. Examples and practice problems will be drawn from biomedical research. Learn how to analyze data and interpret statistical analysis presented in research papers, and will get practical hands-on experience implementing these tools during class in a computer lab setting.

B M E 330 — Engineering Principles of Molecules, Cells, and Tissues

4 credits.

Introduction to the fundamental principles of kinetics and transport that are relevant for the analysis of biological systems. Topics covered include concepts of reaction rate, stoichiometry, equilibrium, momentum/mass transport, and the interaction between transport and kinetics in biological systems.

B M E 389 — Honors in Research

1-3 credits.

Undergraduate honors research projects supervised by faculty members.

B M E 399 — Independent Study

1-3 credits.

Directed study projects as arranged with instructor.

B M E 400 — Capstone Design Course in Biomedical Engineering

3 credits.

Applies classroom study and prior design course experiences for senior teams to solve a directed client-based biomedical engineering design project.

B M E 402 — Biomedical Engineering Capstone Design II

3 credits.

Work in a team to evaluate, refine, document and present the client-centered biomedical engineering design started in B M E 400.

B M E/​M E  414 — Orthopaedic Biomechanics - Design of Orthopaedic Implants

3 credits.

Apply the design process for orthopaedic implants (total joint replacements). Topics include: library skills; joint anatomy; tissue properties; surgical approach; joint loading; implants materials; preclinical testing and analysis.

B M E/​M E  415 — Biomechanics of Human Movement

3 credits.

An overview of experimental and modeling techniques used to study human movement. Specific topics will include locomotion, motion capture systems, force plates, muscle mechanics, musculoskeletal modeling, three dimensional kinematics, inverse dynamics, forward dynamic simulation and imaging based biomechanics. Homework and laboratory activities emphasize applications of movement biomechanics in orthopedics and rehabilitation.

B M E/​PHM SCI  430 — Biological Interactions with Materials

3 credits.

Addresses the range of materials currently being utilized for various biomedical applications, the biological systems governing biomaterial applications, analytical techniques pertinent to biomaterial evaluation, and selected major medical applications in which biomaterials play an important role.

B M E/​E C E  462 — Medical Instrumentation

3 credits.

Design and application of electrodes, biopotential amplifiers, biosensors, therapeutic devices. Medical imaging. Electrical safety. Measurement of ventilation, blood pressure and flow.

B M E/​E C E  463 — Computers in Medicine

3 credits.

Study of microprocessor-based medical instrumentation. Emphasis on real-time analysis of electrocardiograms. Labs and programming project involve design of biomedical digital signal processing algorithms. Knowledge of computer programming language like C, C++ or Java, strongly encouraged.

B M E 489 — Honors in Research

1-3 credits.

Biomedical engineering undergraduate honors research projects supervised by faculty members.

B M E/​H ONCOL/​MED PHYS/​PHYSICS  501 — Radiation Physics and Dosimetry

3 credits.

Interactions and energy deposition by ionizing radiation in matter; concepts, quantities and units in radiological physics; principles and methods of radiation dosimetry.

B M E/​M E  505 — Biofluidics

3 credits.

Introduction to the physics of biological fluid flow with an emphasis on the cardiovascular system including blood rheology, pulsatile flow, wave travel, and topics relevant to blood flow measurement and biomedical device design.

B M E 510 — Introduction to Tissue Engineering

3 credits.

Overview of tissue engineering, including discussion of cell sources, cell-material interactions, tailoring biomaterials, methods of culture and characterization of engineering tissues, ethical issues, concluding with case studies of specific types of tissue engineering. Optional laboratory exercises offered throughout semester.

B M E 511 — Tissue Engineering Laboratory

1 credit.

Tissue engineering refers to the generation of biological substitutes to restore, maintain, or improve tissue function. Laboratory techniques are multi-disciplinary, from basic biological sciences, engineering, and biotechnology. Engineering approaches and analysis will be applied to these techniques.

B M E 515 — Therapeutic Medical Devices

1 credit.

Design of medical devices to treat pathology.

B M E/​M E  516 — Finite Elements for Biological and Other Soft Materials

3 credits.

Finite element modeling of soft materials, with an emphasis on biological tissues. Basics of the finite element method, verification and validation methods, and selection of constitutive models. Emphasis on finite element modeling for materials that are generally nonlinear, and that generally undergo large deformation.

B M E 517 — Biology in Engineering Seminar

1 credit.

Current topics at the interface of biology and engineering with special emphasis on the ways in which engineers have contributed to knowledge and advances in biology.

B M E 520 — Stem Cell Bioengineering

3 credits.

Covers engineering approaches that are used to understand and manipulate stem cells. Concepts covered include: introduction to stem cell biology, quantitative modeling of stem cell signaling, methods to engineer the stem cell microenvironment, and the role of stem cells in tissue development and regeneration.

B M E/​MED PHYS  530 — Medical Imaging Systems

3 credits.

2D Fourier image representation, sampling, and image filtering with applications in medical imaging. Principles of operation, impulse responses, signal-to-noise, resolution and design tradeoffs in projection radiography, tomography, nuclear medicine, ultrasound, and magnetic resonance imaging.

B M E/​MED PHYS  535 — Introduction to Energy-Tissue Interactions

3 credits.

Explore physical interactions between thermal, electromagnetic and acoustic energies and biological tissues with emphasis on therapeutic medical applications.

B M E 545 — Engineering Extracellular Matrices

3 credits.

Overview of the structure, function and biophysical properties of extracellular matrix (ECM) proteins, followed by discussion of how control or manipulation of ECM protein expression and distribution impacts on cell and tissue function, concluding with impacts of engineering ECM for regenerative medicine.

B M E 550 — Introduction to Biological and Medical Microsystems

3 credits.

Introduction to the field of MEMS (Micro-Electro-Mechanical-Systems), as it applies to biology and medicine. Topics will cover methodology of traditional MEMS devices, how they can be incorporated with biological systems, and methods for micro-structuring biological materials.

B M E 556 — Systems Biology: Mammalian Signaling Networks

3 credits.

Introduction to the experimental and mathematical modeling techniques used in systems biology through lectures and critical analyses of relevant publications with a primary focus on gene/protein networks and mammalian systems.

B M E/​CBE  560 — Biochemical Engineering

3 credits.

Properties of biological molecules; enzyme kinetics, enzyme reactors, and enzyme engineering; metabolic engineering; microbial growth kinetics; bioreactor design; bioseparations.

B M E/​I SY E  564 — Occupational Ergonomics and Biomechanics

3 credits.

Introduces engineers how to design manufacturing and industrial operations in which people play a significant role, so that human capabilities are maximized, physical stress is minimized, and workload is optimized. Examples and topics emphasize industrial applications.

B M E/​MED PHYS  566 — Physics of Radiotherapy

3 credits.

Ionizing radiation use in radiation therapy to cause controlled biological effects in cancer patients. Physics of the interaction of the various radiation modalities with body-equivalent materials, and physical aspects of clinical applications.

B M E/​MED PHYS  567 — The Physics of Diagnostic Radiology

4 credits.

Physics of x-ray diagnostic procedures and equipment, radiation safety, general imaging considerations; lecture and lab.

B M E/​MED PHYS  568 — Magnetic Resonance Imaging (MRI)

2 credits.

Core course covering the physics associated with magnetic resonance imaging emphasizing techniques employed in medical diagnostic imaging. Major MRI topics include: physics of MR, pulse sequences, hardware, imaging techniques, artifacts, and clinical applications. At the completion of this course, students should have an understanding of the technical and scientific details of modern magnetic resonance imaging and its use in diagnosing disease. Graduate students who have not taken MATH 222 and PHYSICS 202 at UW-Madison must have the equivalent coursework in order to be successful in this course.

B M E/​MED PHYS  573 — Mathematical Methods in Medical Physics

3 credits.

Mathematical fundamentals required for medical physics and biomedical applications, including signal analysis and mathematical optimization.

B M E/​MED PHYS  574 — Data Science in Medical Physics

3 credits.

Concepts and principles of statistics and machine learning for medical physics-related research problems. Topics covered include probability and independence, discrete and continuous random variables and statistical distributions, random sampling and central limit theorem, inference for means, variances, proportions, moment generating functions, maximum likelihood, hypothesis testing, ANOVA, linear regression, correlation and basic design of experiments with application to quality assurance, reliability, and reproducibility.

B M E/​MED PHYS  575 — Diagnostic Ultrasound Imaging

2 credits.

Propagation of ultrasonic waves in biological tissues; principles of ultrasonic measuring and imaging instrumentation; design and use of currently available tools for performance evaluation of diagnostic instrumentation; biological effects of ultrasound.

B M E/​MED PHYS  578 — Non-Ionizing Diagnostic Imaging

4 credits.

Covers the physics associated with magnetic resonance imaging and diagnostic ultrasound emphasizing techniques employed in medical diagnostic imaging. Major MRI topics include: physics of MR, pulse sequences, hardware, imaging techniques, artifacts, and spectroscopic localization. Ultrasound based topics covered include: propagation of ultrasonic waves in biological tissues, principles of ultrasonic measuring and imaging instrumentation, design and use of currently available tools for performance evaluation of diagnostic instrumentation, and biological effects of ultrasound. Gain an understanding of the technical and scientific details of modern non-ionizing medical magnetic resonance and ultrasound devices and their use in diagnosing disease.

B M E/​MED PHYS  580 — The Physics of Medical Imaging with Ionizing Radiation

4 credits.

Concepts and principles on the physics of medical imaging systems that form images using high energy photons are presented. Such systems are divided into two categories: (1) those based on the transmission of x-rays through the human body, including radiography, mammography, fluoroscopy, and computed tomography (CT), and (2) those based on the emission of gamma rays or annihilation radiation following radioactive decay of an internal radiolabeled molecule, including the gamma camera, single photon emission tomography (SPECT), and positron emission tomography (PET) and PET hybrid imaging systems. Emphasis is placed on understanding how physics, system design, and imaging technique determine image performance metrics such as contrast, signal-to-noise ratio, and spatial resolution. Clinical applications and radiation safety concepts are detailed for the different types of imaging systems.

B M E 601 — Special Topics in Biomedical Engineering

1-3 credits.

Directed study projects as arranged with instructor.

B M E 602 — Special Topics in Biomedical Engineering

1-3 credits.

Special topics in biomedical engineering for graduate students or both graduate and undergraduate students together.

B M E/​M E  603 — Topics in Bio-Medical Engineering

1-3 credits.

Various aspects of living systems of interest to the mechanical engineer, such as the mechanics of hearing and vision, cardiac and central nervous systems, artificial organs, blood flow behavior, and energy-transfer processes.

B M E/​M E  615 — Tissue Mechanics

3 credits.

Focus on solid mechanics of prominent musculoskeletal and cardiovascular tissues. Their normal and pathological behaviors (stiffness, strength, relaxation, creep, adaptive remodeling, etc.) in response to physiologic loading will be examined and quantified.

B M E/​MED PHYS/​PHMCOL-M/​PHYSICS/​RADIOL  619 — Microscopy of Life

3 credits.

Survey of state of the art microscopic, cellular and molecular imaging techniques, beginning with subcellular microscopy and finishing with whole animal imaging.

B M E 630 — Nanomaterials for Biomedical Applications

3 credits.

An in-depth discussion of the chemistry, structure, synthesis/fabrication, and properties of various types of nanomaterials (e.g., liposomes, polymer micelles, polymersomes, dendrimers, and a number of inorganic nanoparticles) and their applications in therapeutics (e.g., drug and gene delivery), diagnostics (e.g. biosensing and molecular imaging), and tissue engineering.

B M E 640 — Medical Devices Ecosystem: The Path to Product

3 credits.

Development of medical devices for therapeutic or diagnostic purposes. Gap analysis, market analysis, reimbursement/distribution, regulatory approval, and manufacturing/supply chain development. Refinement and presentation of design ideas and corporate strategy within a team setting. Case studies of device design/manufacture including supply chain, intellectual property, pre-clinical testing, U.S. and European regulatory pathways and clinical trial design.

B M E 651 — Biophotonics Laboratory

3 credits.

Learn and apply the fundamentals of optical imaging, microscopy and instrumentation via practical hands-on training with a specific emphasis on the life-sciences applications. Topics include constructing imaging systems using fundamental optical tools and instruments, illumination and aberrations, microscopy techniques, resolution and contrast measurement, optical spectroscopy, nanophotonics, bioimaging and biosensing.

B M E/​I SY E  662 — Design and Human Disability and Aging

3 credits.

Design of products for persons with physical, sensory or cognitive impairments is covered as well as the design of standard mass market products. Interdisciplinary teams explore specific disabilities, then design a standard mass market product in competition with each other.

B M E/​CRB  670 — Biology of Heart Disease and Regeneration

3 credits.

Presents diverse topics in contemporary heart biology to facilitate understanding of biological, mechanistic, and experimental concepts of cardiac physiology, disease, and regeneration. Learn cellular and molecular mechanisms underlying heart physiology, function, disease and regenerative ability in various model systems. Includes thinking critically about methodology, experimental design and interpretation, and how conclusions are reached in heart biology through cutting-edge literature.

B M E 701 — Seminar in Biomedical Engineering

1 credit.

Presentation of advancements in biomedical engineering research by leaders in the field, accompanied by critical analysis of related literature.

B M E 702 — Graduate Cooperative Education Program

1-2 credits.

Work experience that combines classroom theory with practical knowledge of operations to provide students with a background on which to develop and enhance a professional career. The work experience is tailored for MS students from within the U.S. as well as eligible international students.

B M E 703 — Responsible Conduct of Research for Biomedical Engineers

2 credits.

Develop an understanding of the elements involved in being a responsible member of the Biomedical Engineering research community. Topics include mentor/mentee relationships, identifying research problems, research integrity, ethics, regulations, and improving the scientific climate.

B M E/​MED PHYS  710 — Advances in Medical Magnetic Resonance

3 credits.

Addresses the theory and applications of magnetic resonance (MR) in medicine, by providing the necessary theoretical background to understand advanced MR techniques including magnetic resonance imaging (MRI).

B M E/​M E  715 — Advanced Tissue Mechanics

3 credits.

Central topics in solid mechanics applied to soft tissues, including analysis of strain in the setting of large deformations, computation of stress in multiple experimental loading configurations, constitutive modeling of biomaterials using hyperelastic strain-energy functions, modeling tissue growth and remodeling, and the main theories for soft tissue failure will be covered. Application of finite elasticity theory in practical laboratory situations, and key papers and concepts in soft tissue mechanics.

B M E 740 — Biomanufacturing Entrepreneurship

3 credits.

Industry-relevant concepts of biotechnology innovation and translation, directly connecting lessons and classwork to real-world experience and career opportunities and promoting meaningful and sustained engagement between students and industry representatives. Diverse range of translational biotechnology principles, such as product development in biotechnology, regulating biotechnology products, and quality and compliance in biomanufactured products.

B M E/​CHEM/​MED PHYS  750 — Biological Optical Microscopy

3 credits.

Covers several aspects of state-of-the-art biological and biophysical imaging with an emphasis on instrumentation, beginning with an overview of geometrical optics and optical and fluorescence microscopy. The bulk of the course will focus on advanced imaging techniques including nonlinear optical processes (multi-photon excitation, second harmonic generation, and stimulated Raman processes) and emerging super-resolution methods. Special emphasis will be given to current imaging literature and experimental design. Knowledge of physics-based optics [such as PHYSICS 202] strongly recommended.

B M E 751 — Biomedical Optics and Biophotonics

3 credits.

The study and use of light in the life sciences. Interactions of light with cells and tissue can be used for imaging, measurement, diagnosis, and therapy. Applications include optical imaging, endoscopy, microscopy, resolution enhancement, adaptive optics, Optical Coherence Tomography (OCT), quantitative phase microscopy, spectroscopy (fluorescence, elastic scattering), diffuse optical tomography, and computational modeling of light transport in tissue. Fundamental skills, concepts, and theory used for these applications include geometric optics, lens design, Fourier transforms, polarization, interference, coherence, and scattering theory. Particular emphasis will be placed on current literature and cutting edge instruments and methods.

B M E/​E C E/​MED PHYS  778 — Machine Learning in Ultrasound Imaging

3 credits.

Concepts and machine learning techniques for ultrasound beamforming for image formation and reconstruction to image analysis and interpretation will be presented. Key machine learning and deep learning concepts applied to beamforming, compressed sampling, speckle reduction, segmentation, photoacoustics, and elasticity imaging will be evaluated utilizing current peer-reviewed publications.

B M E 780 — Methods in Quantitative Biology

1 credit.

Focuses on understanding the key methods and principles of quantitative biology through a close reading of the primary literature. Topics covered will include deterministic and stochastic methods for modeling cellular systems, techniques in systems and synthetic biology, image processing tools and image analysis for biology, data-driven network models, genomic approaches, single-molecule approaches, and key computational biology tools. This course is intended for graduate students from a variety of backgrounds who are interested in pursuing quantitative biology during their graduate studies.

B M E/​CBE  782 — Modeling Biological Systems

3 credits.

Literature survey of mathematical models in biology at the molecular and cellular levels; application of chemical kinetics and thermodynamics to biological systems; comparison of deterministic and stochastic strategies.

B M E/​CBE  783 — Design of Biological Molecules

3 credits.

Introduction to the methodologies for engineering the structure and function of biological molecules, especially proteins. Develop an understanding for the integration of computation and experiment to address biological molecular engineering problems. Knowledge of biochemistry and cell biology [such as BIOCHEM 501 or ZOOLOGY 570] required.

B M E 790 — Master's Research and Thesis

1-9 credits.

Under faculty supervision.

B M E 799 — Advanced Independent Study

1-5 credits.

Under faculty supervision.

B M E 890 — Pre-dissertation Research

1-9 credits.

Under faculty supervision.

B M E/​B M I/​BIOCHEM/​CBE/​COMP SCI/​GENETICS  915 — Computation and Informatics in Biology and Medicine

1 credit.

Participants and outside speakers will discuss current research in computation and informatics in biology and medicine. This seminar is required of all CIBM program trainees.

B M E 990 — Research and Thesis

1-9 credits.

Under faculty supervision.

B M E 999 — Advanced Independent Study

1-9 credits.

Under faculty supervision.